Case Series: Hyperbilirubinemia under elexacaftor/tezacaftor/ivacaftor in the presence of Gilbert’s syndrome

Abstract Liver-related side effects are a known complication of treatment with elexacaftor/tezacaftor/ivacaftor (ETI) for cystic fibrosis (CF). Gilbert’s syndrome is caused by a genetic mutation that reduces activity of the enzyme UDP glucuronosyltransferase 1 polypeptide A1 (UGT1A1), causing elevat...

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Principais autores:	Julia Weitzel, Matthias Welsner, Christian Taube, Manfred Ballmann, Sivagurunathan Sutharsan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-07-01
coleção:	BMC Pulmonary Medicine
Assuntos:	Cystic fibrosis Elexacaftor/tezacaftor/ivacaftor Hyperbilirubinemia Gilbert’s syndrome Liver dysfunction Drug intolerance
Acesso em linha:	https://doi.org/10.1186/s12890-024-03114-6
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