Formation of morpholine-acetamide derivatives as potent anti-tumor drug candidates: Pharmacological evaluation and molecular docking studies

Heterocyclic amines and acetamide derivatives are known for their chemotherapeutic potential. Hence, in the present study, morpholine was taken as a principal product and novel morpholine derivatives were designed, formulated, characterized, and screened for the mechanism of inhibition of carbonic a...

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Principais autores:	Ahmed Sadiq Sheikh, Reem Altaf, Humaira Nadeem, Muhammad Tariq Khan, Babar Murtaza
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-11-01
coleção:	Heliyon
Assuntos:	Heterocyclic amines Morpholine based compounds Anti-tumor activity MTT (3-[4,5-dimethylthiazole-2-yl]-2,5 diphenyl tetrazolium bromide) assay Carbonic anhydrase inhibition HIF-1α
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S240584402309391X
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