HMGB1-mediated macrophage polarization to M2 phenotype promotes ureteral stricture: therapeutic potential of HMGB1 inhibitors

Abstract Background Ureteral stricture is a common condition characterized by fibrotic narrowing of the ureter, often resulting in obstruction and impaired renal function. The condition is typically associated with chronic inflammation, epithelial injury, and abnormal wound healing responses, leadin...

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Auteurs principaux:	Jie Zheng, Lingsong Tao, Yingqing Liu, Yang Zhang, Li Cheng, Zongyao Hao
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-09-01
Collection:	European Journal of Medical Research
Sujets:	HMGB1 Ureteral stricture Macrophage polarization TGF-β Fibroblast activation Glycyrrhizin
Accès en ligne:	https://doi.org/10.1186/s40001-025-03137-7
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