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Identification of two KPC variants, KPC-204 and KPC-227, in ST11-K64 Klebsiella pneumoniae during prolonged hospitalization of a single patient

IntroductionCarbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global public health challenge due to its significant association with morbidity and mortality. Ceftazidime-avibactam (CZA) has emerged as an effective therapy against CRKP producing the serine carbapenemase KPC; how...

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Hlavní autoři: Shijun Sun, Chaoe Zhou, Haijun Li, Liying Sun, Saiqi Qi, Xinmin Liu, Wanhai Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2025-06-01
Edice:Frontiers in Microbiology
Témata:
KPC variants
carbapenem resistance
ceftazidime-avibactam resistance
Klebsiella pneumonia
antimicrobial susceptibility
On-line přístup:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1543470/full
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