Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show...

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Detalhes bibliográficos

Principais autores:	Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman, Patrick J Paddison, Christina M Lockwood, Nicholas A Vitanza, James M Olson, Kami Ahmad, Steven Henikoff
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2020-09-01
coleção:	eLife
Assuntos:	diffuse midline glioma pediatric cancer histone variants replication-coupled histone deposition
Acesso em linha:	https://elifesciences.org/articles/61090
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