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Expansion of bone marrow adipocytes in obese mice leads to PD-L1-driven bone marrow immunosuppression and osteoclastogenesis

Abstract Bone marrow adipocytes are known to have a critical role within the bone marrow niche. However, our understanding of bone marrow adipose tissue expansion with obesity and the role it plays in immune cell regulation and osteoclastogenesis is limited. Here, we showed the expansion of bone mar...

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Principais autores: Samantha N. Costa, Carolyn Chlebek, Lindsey Gray, Peter Caradonna, Sergey Ryzhov, Clifford J. Rosen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2026-03-01
Series:Bone Research
Acceso en liña:https://doi.org/10.1038/s41413-026-00509-5
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