A NANOBODY molecule that blocks MerTK ectodomain cleavage in vitro and in vivo

The membrane receptor MerTK is critical for the resolution of inflammation and thus is of pharmacological interest. MerTK function is inhibited by the proteolytic cleavage of its extracellular domain leading to the formation of soluble Mer (sMer). We describe here the NANOBODY molecule A0445046C08 a...

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Autors principals:	Linde Duprez, Ayse Kilic, Hélène Bruwiere, Karim Fekir, Dennis Vlaeminck, Camille De Craene, Daan Geiregat, Kirsten Paesen, Lien Leutenez, Stijn Lambrecht, Thomas Van De Velde, Aline Moliere, Judith Verhelst, Edith Stuyven, Soraya Hoelper, Dieter Schmoll
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2026-12-01
Col·lecció:	mAbs
Matèries:	ADAM17 ectodomain shedding efferocytosis immunoglobulin single variable domains resolution of inflammation
Accés en línia:	https://www.tandfonline.com/doi/10.1080/19420862.2026.2704449
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