Targeting IQGAP3 skews macrophages polarization towards M1 phenotype and promotes antitumor immune response

Abstract Objective Immunosuppressive M2 macrophages in the tumor microenvironment (TME) limit the efficacy of immune checkpoint inhibitors (ICIs), with only ∼20% of lung adenocarcinoma (LUAD) patients benefiting from ICI monotherapy. Targeting macrophage polarization represents a promising strategy...

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Principais autores:	Xiao Li, Xiaopeng An, Yuanyi Zhang, Siyuan Zhang, Lizhong Zeng, Jie Shi, Shiqi Wu, Yan Wang, Yao Xu, Xin Lv, Shuanying Yang, Bo Yuan
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer 2025-12-01
Series:	Cellular and Molecular Life Sciences
Assuntos:	Lung adenocarcinoma IQGAP3 Macrophages CD8 + T cells Immunotherapy
Acceso en liña:	https://doi.org/10.1007/s00018-025-06044-6
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