Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures.

Topical preexposure prophylaxis (PrEP) against HIV has been marginally successful in recent clinical trials with low adherence rates being a primary factor for failure. Controlled, sustained release of antiretroviral (ARV) drugs may help overcome these low adherence rates if the product is protectiv...

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Principais autores:	Priya Srinivasan, John A Moss, Manjula Gunawardana, Scott A Churchman, Flora Yang, Chuong T Dinh, James M Mitchell, Jining Zhang, Rob Fanter, Christine S Miller, Irina Butkyavichene, Janet M McNicholl, Thomas J Smith, Marc M Baum, James M Smith
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2016-01-01
Serija:	PLoS ONE
Online dostop:	http://europepmc.org/articles/PMC4898685?pdf=render
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