Mucosal-associated invariant T cells recognize a tumor-derived metabolite in the DNA synthesis pathway

Mucosal-associated invariant T (MAIT) cells recognize metabolite-derived ligands, but the identity of such ligands in the context of cancer remains poorly defined. Herein, we demonstrate that the tumor-derived metabolite 5-formyl tetrahydrofolate (5-formyl THF), which is an intermediate of the folat...

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Principais autores:	Yanqi Xue, Yuka Yamada, Rikako Suzuki, Brenda Luong, Shotaro Fujii, Keisuke Nakata, Masatomo Takahashi, Yoshihiro Izumi, Chihiro Fukui, Ryosuke Takasaki, Francois Legoux, Shinsuke Inuki, Daisuke Motooka, Emi Ito, Bridget L. Stocker, Mattie S. M. Timmer, Takashi Shimizu, Yasumasa Matsuoka, Jun’ichi Mano, Koji Tamada, Makoto Furutani-Seiki, Kei Sakamoto, Koh-Hei Sonoda, Olivier Lantz, Sho Yamasaki, Kensuke Shibata
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-06-01
Serija:	Frontiers in Immunology
Teme:	cancer DNA synthesis ligand metabolite T cells
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797918/full
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