Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer

Abstract Background Cancer-associated fibroblasts (CAFs), known for facilitating the progression and metastasis of colorectal cancer (CRC), have become a promising therapeutic target. However, the significant heterogeneity of CAFs and their intricate crosstalk with tumor cells present substantial ch...

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Detalhes bibliográficos

Principais autores:	Yunfei Lu, Yang Chen, Zhenling Wang, Hengyang Shen, Lei Xu, Changzhi Huang, Ying Tong, Yu Shao, Hongqiang Zhang, Zan Fu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-03-01
coleção:	Journal of Translational Medicine
Assuntos:	Colorectal cancer Single-cell RNA sequencing Spatial transcriptomics WNT5A EMT
Acesso em linha:	https://doi.org/10.1186/s12967-025-06236-5
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