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Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells

Purinergic P2X7 receptors (P2X7) have now been proven to play an important role and represent an important therapeutic target in many pathological conditions including neurodegeneration. Here, we investigated the impact of peptides on purinergic signaling in Neuro-2a cells through the P2X7 subtype i...

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Автори: Evgeny A. Pislyagin, Ekaterina S. Menchinskaya, Irina N. Gladkikh, Aleksandra N. Kvetkina, Oksana V. Sintsova, Darya V. Popkova, Sergei A. Kozlovskiy, Tatiana Y. Gorpenchenko, Galina N. Likhatskaya, Leonid A. Kaluzhskiy, Alexis S. Ivanov, Yaroslav A. Andreev, Sergey A. Kozlov, Pavel S. Dmitrenok, Dmitry L. Aminin, Elena V. Leychenko
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2023-03-01
Серія:Marine Drugs
Предмети:
P2X7 receptor
Ca<sup>2+</sup> influx
dye uptake
molecular docking
Kunitz-type peptides
neuroprotective activity
Онлайн доступ:https://www.mdpi.com/1660-3397/21/3/192
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