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<i>Mycobacterium tuberculosis</i> Central Metabolism Is Key Regulator of Macrophage Pyroptosis and Host Immunity

Metabolic dysregulation in <i>Mycobacterium tuberculosis</i> results in increased macrophage apoptosis or pyroptosis. However, mechanistic links between <i>Mycobacterium</i> virulence and bacterial metabolic plasticity remain ill defined. In this study, we screened random transposon insertions of <i...

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Principais autores: Michelle E. Maxson, Lahari Das, Michael F. Goldberg, Steven A. Porcelli, John Chan, William R. Jacobs
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-08-01
Serier:Pathogens
Fag:
pyroptosis
<i>Mycobacterium</i>
caspase-1
Rv3727
redox balance
Online adgang:https://www.mdpi.com/2076-0817/12/9/1109
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