Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.

We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior. We screened a panel of 14 α1/2- and β1/2/3-AR antagonis...

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Bibliografische gegevens

Hoofdauteurs:	Xianlong Gao, Hazem Abdelkarim, Lauren J Albee, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Public Library of Science (PLoS) 2018-01-01
Reeks:	PLoS ONE
Online toegang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0204041&type=printable
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