Triple‐Combination Immunogenic Nanovesicles Reshape the Tumor Microenvironment to Potentiate Chemo‐Immunotherapy in Preclinical Cancer Models

Abstract Immune checkpoint blockade (ICB) therapies have had a tremendous impact on cancer therapy. However, most patients harbor a poorly immunogenic tumor microenvironment (TME), presenting overwhelming de novo refractoriness to ICB inhibitors. To address these challenges, combinatorial regimens t...

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Hauptverfasser:	Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2023-05-01
Schriftenreihe:	Advanced Science
Schlagworte:	cancer nanomedicine chemo‐immunotherapy gemcitabine prodrug stimulator of interferon genes agonist tumor microenvironment
Online-Zugang:	https://doi.org/10.1002/advs.202204890
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