A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation

ABSTRACT Attenuation of the live varicella Oka vaccine (vOka) has been attributed to mutations in the genome acquired during cell culture passage of pOka (parent strain); however, the precise mechanisms of attenuation remain unknown. Comparative sequence analyses of several vaccine batches showed th...

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Detalles Bibliográficos

Principais autores:	Tomohiko Sadaoka, Daniel P. Depledge, Labchan Rajbhandari, Judith Breuer, Arun Venkatesan, Jeffrey I. Cohen
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2022-08-01
Series:	mBio
Assuntos:	attenuation mechanism glycoprotein B live attenuated varicella vaccine varicella-zoster virus virus fusogen
Acceso en liña:	https://journals.asm.org/doi/10.1128/mbio.01864-22
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