Precision Fc remodeling via glycosylation-competent CHO display enables ultra-selective FcγRIIIa targeting and enhanced antitumor activity

Abstract Background Improving tumor cell clearance by therapeutic antibodies remains a translational bottleneck because wild-type IgG1 Fc typically elicits suboptimal NK cell–mediated antibody-dependent cellular cytotoxicity (ADCC), necessitating Fc engineering to enhance activating FcγR engagement...

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Detalhes bibliográficos

Principais autores:	Migyeong Jo, Suyeon Kim, Sanghwan Ko, Munsu Kyung, Seunghyeon Lee, Woo Hyung Ko, Wonju Lee, Sang Taek Jung
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Journal of Biological Engineering
Assuntos:	Therapeutic IgG antibody FcγRIIIa CHO-based mammalian display Fc engineering Target cell lysis
Acesso em linha:	https://doi.org/10.1186/s13036-026-00671-8
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