Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer

Abstract Background Studies have shown that oxidative stress and its resistance plays important roles in the process of tumor metastasis, and mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage is an important molecular event in oxidative stress. In lung cancer, the normal fibroblas...

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Detalhes bibliográficos

Principais autores:	Zhuan Zhou, Chunhui Qu, Peijun Zhou, Qin Zhou, Dan Li, Xia Wu, Lifang Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Extracellular vesicles Cancer-associated fibroblasts Mitophagy mtDNA Lung cancer Metastasis
Acesso em linha:	https://doi.org/10.1186/s13046-024-03077-w
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