Irisin inhibits adipogenic differentiation of bone marrow mesenchymal stem cells through the SIRT1/RANBP2/FTO signaling axis and protects against osteoporosis

Abstract Abnormal bone marrow obesity caused by the conversion of bone marrow mesenchymal stem cells (BMMSCs) from osteoblast to adipocyte differentiation is one of the significant contributors to age and menopause-related osteoporosis (OP) development. Irisin, one of the myokines, has been reported...

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Autori principali:	Junfei Chen, Jincheng Liu, Qingyang Fu, Mingyu Xu, Xu Zhai, Le Li, Wanlong Xu, Xinhui Wu, Kaidi Wang, Haipeng Si
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2026-02-01
Serie:	Cell Death Discovery
Accesso online:	https://doi.org/10.1038/s41420-026-02976-5
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