Irisin inhibits adipogenic differentiation of bone marrow mesenchymal stem cells through the SIRT1/RANBP2/FTO signaling axis and protects against osteoporosis

Abstract Abnormal bone marrow obesity caused by the conversion of bone marrow mesenchymal stem cells (BMMSCs) from osteoblast to adipocyte differentiation is one of the significant contributors to age and menopause-related osteoporosis (OP) development. Irisin, one of the myokines, has been reported...

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Ngā kaituhi matua:	Junfei Chen, Jincheng Liu, Qingyang Fu, Mingyu Xu, Xu Zhai, Le Li, Wanlong Xu, Xinhui Wu, Kaidi Wang, Haipeng Si
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Publishing Group 2026-02-01
Rangatū:	Cell Death Discovery
Urunga tuihono:	https://doi.org/10.1038/s41420-026-02976-5
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!