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Angiotensin receptor blockers modulate the lupus CD4+ T cell epigenome characterized by TNF family–linked signaling

In systemic lupus erythematosus (lupus), environmental effects acting within a permissive genetic background lead to autoimmune dysregulation. Dysfunction of CD4+ T cells contributes to pathology by providing help to autoreactive B and T cells, and CD4+ T cell dysfunction coincides with altered DNA...

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Principais autores: Andrew P. Hart, Jonathan J. Kotzin, Steffan W. Schulz, Jonathan S. Dunham, Alison L. Keenan, Joshua F. Baker, Andrew D. Wells, Daniel P. Beiting, Terri M. Laufer
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2025-02-01
Serier:JCI Insight
Fag:
Autoimmunity
Immunology
Online adgang:https://doi.org/10.1172/jci.insight.176811
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