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Runx2 acetylation enhances pulmonary inflammation in chronic obstructive pulmonary disease through activating CDK8

Abstract Background Runt-related transcription factor 2 (Runx2), a transcription factor of the RUNX family, is involved in various inflammatory diseases. However, the role of Runx2 was unclear in chronic obstructive pulmonary disease (COPD). Methods Pulmonary Runx2 level was compared in COPD patient...

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Principais autores: Yi-Cheng Ma, Dan-Lei Chen, Ju-Hong Wu, Fei Tang, Tian-Rui Sui, Zhi-Yong Wu, Qi-Yuan He, Yu Wang, Min-Min Tang, Dong-Xu Hua, Jing Yang, Hui Zhao, Jun Fei, Wei Cao, Lin Fu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Respiratory Research
Assuntos:
COPD
Runx2
Sirtuin 3
CDK8
Inflammation
Acesso em linha:https://doi.org/10.1186/s12931-025-03475-4
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