Amonafide Targeting NTSR1‐PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension

Background Pulmonary arterial hypertension (PAH) is a progressive disease driven by pulmonary vascular remodeling, largely due to the abnormal proliferation and phenotypic switching of pulmonary artery smooth muscle cells. Methods Levels of topoisomerase II α were evaluated in the lungs from patient...

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Hlavní autoři:	Yong‐Jian Zhu, Jie‐Jian Kou, Ya‐Cong Bo, Meng‐Jie Zhang, Xin Fan, Lu‐Ling Zhao, Yi Yan, Hong‐Da Zhang, Wen‐Hui Wu, Ping Yuan, Yan Liu, Jun‐Zhuo Shi, Xiao‐Bin Pang, Yang‐Yang He
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-05-01
Edice:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Témata:	amonafide NTSR1 pulmonary arterial hypertension topoisomerase II α vascular remodeling
On-line přístup:	https://www.ahajournals.org/doi/10.1161/JAHA.125.045580
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