<i>ERG3</i>-Encoding Sterol C5,6-DESATURASE in <i>Candida albicans</i> Is Required for Virulence in an Enterically Infected Invasive Candidiasis Mouse Model

Gastrointestinal colonization by <i>Candida</i> species is considered the main source of candidemia. The <i>ERG3</i> gene in <i>Candida albicans</i> encodes a sterol C5,6-desaturase, which is essential for ergosterol biosynthesis. Although <i>ERG3</i> inactivation shows reduced virulence in mouse mo...

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Detalhes bibliográficos

Principais autores:	Tatsuro Hirayama, Taiga Miyazaki, Makoto Sumiyoshi, Nobuyuki Ashizawa, Takahiro Takazono, Kazuko Yamamoto, Yoshifumi Imamura, Koichi Izumikawa, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-12-01
coleção:	Pathogens
Assuntos:	<i>Candida albicans</i> <i>ERG3</i> ergosterol pathogenesis colonization intestinal tract
Acesso em linha:	https://www.mdpi.com/2076-0817/10/1/23
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