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FRZB-induced anti-angiogenic effect via Caveolin-1-mediated TGFβ signalling

Abstract Pathological neovascularization and vascular leakage are central drivers of many sight-threatening diseases. While strategies targeting vascular endothelial growth factor (VEGF) have improved clinical outcomes, many patients do not benefit from the treatment, highlighting the need for alter...

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Autors principals: Ching-Jou Chen, Lei Zhou, Han-Tang Chen, Veluchamy Amutha Barathi, Beiying Qiu, Asfa Alli-Shaik, Rui Ning Chia, Seok Ting Lim, Chaemin Joo, Ning Cheung, Choi Mun Chan, Siew Kwan Koh, Alison Tan, Ravi Kumar Verma, Hao Fan, Weihua Song, David Virshup, Jayantha Gunaratne, Tien Yin Wong, Gemmy Chui Ming Cheung, Wanjin Hong, Xiaomeng Wang
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2026-04-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-026-71326-x
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