A metabolic redox relay supports ER proinsulin export in pancreatic islet β cells
ER stress and proinsulin misfolding are heralded as contributing factors to β cell dysfunction in type 2 diabetes, yet how ER function becomes compromised is not well understood. Recent data identify altered ER redox homeostasis as a critical mechanism that contributes to insulin granule loss in dia...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical investigation
2024-08-01
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| coleção: | JCI Insight |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1172/jci.insight.178725 |
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