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A metabolic redox relay supports ER proinsulin export in pancreatic islet β cells

ER stress and proinsulin misfolding are heralded as contributing factors to β cell dysfunction in type 2 diabetes, yet how ER function becomes compromised is not well understood. Recent data identify altered ER redox homeostasis as a critical mechanism that contributes to insulin granule loss in dia...

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Principais autores: Kristen E. Rohli, Nicole J. Stubbe, Emily M. Walker, Gemma L. Pearson, Scott A. Soleimanpour, Samuel B. Stephens
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical investigation 2024-08-01
סדרה:JCI Insight
נושאים:
Cell biology
Endocrinology
גישה מקוונת:https://doi.org/10.1172/jci.insight.178725
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