The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain.

The majority of HIV-1 strains enter CD4+ T cells using the CCR5 and/or CXCR4 co-receptor. However, we recently identified a transmitted/founder (T/F) virus (ZP6248) that efficiently used an alternative coreceptor GPR15, rather than commonly used CXCR4 and CCR5, to establish clinical infection. To un...

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Detalhes bibliográficos

Principais autores:	Yue Xiang, Wei Liu, Yue Chen, Chuntao Zhang, Weiheng Su, Yan Zhang, Jiaxi Sun, Feng Gao, Chunlai Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4045670?pdf=render
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