Tumor derived exosomal ENTPD2 impair CD8+ T cell function in colon cancer through ATP-adenosine metabolism reprogramming

Abstract Background Extracellular ATP–AMP–adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the conversion of ATP to AMP is primarily catalysed by Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1/CD39), a widely studied ATPase, w...

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Hlavní autoři:	Mengchen Shi, Linsen Ye, Lu Zhao, Lingyuan He, Junxiong Chen, Jingdan Zhang, Yixi Su, Haiyan Dong, Jiaqi Liu, Liumei Liang, Wenwen Zheng, Yanhong Xiao, Huanliang Liu, Xiangling Yang, Zihuan Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-05-01
Edice:	Cell Communication and Signaling
Témata:	Colon cancer Exosome Adenosine Ectonucleoside triphosphate diphosphohydrolase CD8+ T cell
On-line přístup:	https://doi.org/10.1186/s12964-024-01654-2
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