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Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. SPL generates a S1P chemical gradient that promotes...

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Principais autores: Alexander D. Borowsky, Padmavathi Bandhuvula, Ashok Kumar, Yuko Yoshinaga, Mikhail Nefedov, Loren G. Fong, Meng Zhang, Brian Baridon, Lisa Dillard, Pieter de Jong, Stephen G. Young, David B. West, Julie D. Saba
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012-09-01
Colecção:Journal of Lipid Research
Assuntos:
sphingosine phosphate lyase
colon cancer
development
sphingolipid
signal transduction
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520418346
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