Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural data has expanded our understanding of GPCR-mediat...

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Detalhes bibliográficos

Principais autores:	Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Shoji Maeda, Tilman Flock, Nicholas MI Taylor, Inayatulla Mohammed, Hugues Matile, Roger JP Dawson, Xavier Deupi, Henning Stahlberg, Gebhard Schertler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2019-06-01
coleção:	eLife
Assuntos:	G protein-coupled receptors G proteins cryo-EM Gβ subunit cellular signaling Bos taurus
Acesso em linha:	https://elifesciences.org/articles/46041
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