Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis

Abstract Background In Alzheimer’s disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood–cerebrospinal fluid barrier could provide further insight into the epithelial and stromal responses to neurod...

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Detalhes bibliográficos

Principais autores:	Edward G. Stopa, Keith Q. Tanis, Miles C. Miller, Elena V. Nikonova, Alexei A. Podtelezhnikov, Eva M. Finney, David J. Stone, Luiz M. Camargo, Lisan Parker, Ajay Verma, Andrew Baird, John E. Donahue, Tara Torabi, Brian P. Eliceiri, Gerald D. Silverberg, Conrad E. Johanson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-05-01
coleção:	Fluids and Barriers of the CNS
Assuntos:	Choroid plexus transcriptome Neuroimmune CSF regulation Blood–CSF barrier inflammatome Janus kinase/signal transducers and activators of transcription (JAK-STAT) Peroxisome-proliferator-activated receptor (PPAR) Cadherin-mediated adhesion
Acesso em linha:	http://link.springer.com/article/10.1186/s12987-018-0102-9
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