Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors
In this study, newly synthesised compounds 6, 8, 10 and other compounds (1–5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1–10 showed effective inhibition profiles with KI values in the range of 5.13–16.9 nM for hCA...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis Group
2020-01-01
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| Col·lecció: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Matèries: | |
| Accés en línia: | http://dx.doi.org/10.1080/14756366.2019.1695791 |
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