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Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles

Enterovirus D68 (EV-D68) has emerged as a significant respiratory pathogen that can cause severe respiratory disease and acute neurologic disease. At present, there are no approved antiviral agents or vaccines for EV-D68. In this study, we demonstrate that andrographolide (ADO), an active component...

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Principais autores: Dongyin Wang, Haoran Guo, Junliang Chang, Dong Wang, Bin Liu, Pujun Gao, Wei Wei
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-10-01
Serier:Frontiers in Microbiology
Fag:
enterovirus D68
andrographolide
endocytosis
acidification
drug development
Online adgang:https://www.frontiersin.org/article/10.3389/fmicb.2018.02407/full
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