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Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD)...

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Principais autores: Jean Claude Alvarez, Benjamin Davido, Pierre Moine, Isabelle Etting, Djillali Annane, Islam Amine Larabi, Nicolas Simon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-02-01
coleção:Pharmaceuticals
Assuntos:
hydroxychloroquine
desethylhydroxychloroquine
desethylchloroquine
didesethylchloroquine
PK/PD
COVID-19
Acesso em linha:https://www.mdpi.com/1424-8247/15/2/256
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