Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients

L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) signalling. Despite their physiological relevance in modulating cerebral activity, serine enantiomers metabolism in Par...

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Detalhes bibliográficos

Principais autores:	Anna Di Maio, Tommaso Nuzzo, Luana Gilio, Marcello Serra, Fabio Buttari, Francesco Errico, Arianna De Rosa, Mario Stampanoni Bassi, Micaela Morelli, Jumpei Sasabe, David Sulzer, Manolo Carta, Diego Centonze, Alessandro Usiello
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-08-01
coleção:	Neurobiology of Disease
Assuntos:	biomarkers serine dopamine alanine cysteine serine transporter (SLC1A4) Alzheimer's disease amyotrophic lateral sclerosis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996123002188
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