CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells

Summary: CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or li...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Luke Riggan, Andrew D. Hildreth, Marion Rolot, Yung-Yu Wong, William Satyadi, Ryan Sun, Christopher Huerta, Timothy E. O’Sullivan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-05-01
Schriftenreihe:	Cell Reports
Schlagworte:	CRISPR Cas9 cRNP innate immunity ILC dendritic cell
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124720306045
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