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Targeted disruption of PRC1.1 complex enhances bone remodeling

Abstract Polycomb repressive complexes (PRCs) are pivotal epigenetic regulators that preserve cell identity by restricting transcription responses to sub-threshold extracellular signals. Their roles in osteoblast function and bone formation remain unclear. Here in aging osteoblasts, we found marked...

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Hlavní autoři: Liangyu Xing, Jinxin Xu, Meihan Gong, Yunzhi Liu, Xuanyuan Li, Lingyu Meng, Ruyue Du, Ying Zhou, Zhaoguang Ouyang, Xu Liu, Shaofei Tao, Yuxin Cao, Chunyi Liu, Feng Gao, Ruohui Han, Hui Shen, Yan Dong, Yong Xu, Tao Li, He Chen, Yingying Zhao, Baoyou Fan, Lei Sui, Shiqing Feng, Jinsong Liu, Dayong Liu, Xudong Wu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-05-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-025-59638-w
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