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Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways

Abstract The aquaporin-4 (AQP4) water channel is essential in neurofluid dynamics. AQP4 loss impairs solute exchange between the cerebrospinal fluid (CSF) and interstitial fluid (ISF). However, whether AQP4 expression affects solute clearance from the CSF space to the extracranial space remains uncl...

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שמור ב:
Principais autores: Daisuke Kato, Hiroyuki Kameda, Naoya Kinota, Takaaki Fujii, Bai Xiawei, Zhou Simi, Yoshiki Takai, Simon Chau, Yoshiki Miyasaka, Tomoji Mashimo, Yoichiro Abe, Masato Yasui, Kazuyuki Minowa, Kohsuke Kudo
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2024-11-01
סדרה:Scientific Reports
נושאים:
Aquaporin-4
Glymphatic System
Neurofluid
Dynamic contrast-enhanced MRI
גישה מקוונת:https://doi.org/10.1038/s41598-024-79147-y
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