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Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages

Interferons (IFNs) are a family of cytokines that activate the JAK-STAT signaling pathway to induce an antiviral state in cells. Interleukin 27 (IL-27) is a member of the IL-6 and/or IL-12 family that elicits both pro- and anti-inflammatory responses. Recent studies have reported that IL-27 also ind...

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Principais autores: Juan Felipe Valdés-López, Lady Johana Hernández-Sarmiento, Y. S. Tamayo-Molina, Paula A. Velilla-Hernández, Izabela A. Rodenhuis-Zybert, Silvio Urcuqui-Inchima
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Immunology
Fag:
interleukin 27
interferons
JAK-STAT signaling
interferon-stimulated genes
antiviral response
pro-inflammatory response
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1385473/full
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