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Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas

Although ultra-small nanoclusters (USNCs, < 2 nm) have immense application capabilities in biomedicine, the investigation on body-wide organ responses towards USNCs is scant. Here, applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues, we systematic...

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Principais autores: Tao Zhang, Tingyun Lei, Ruojin Yan, Bo Zhou, Chunmei Fan, Yanyan Zhao, Shasha Yao, Haihua Pan, Yangwu Chen, Bingbing Wu, Yuwei Yang, Lijuan Hu, Shen Gu, Xiaoyi Chen, Fangyuan Bao, Yu Li, Hanqi Xie, Ruikang Tang, Xiao Chen, Zi Yin
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2022-12-01
Serier:Bioactive Materials
Fag:
Nanoparticle
Nanocluster
Single-cell mass cytometry
RNA-Seq
Multi-omics
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X22001426
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