Abnormal adipogenic signaling in the bone marrow mesenchymal stem cells contributes to supportive microenvironment for leukemia development

Abstract Background Acute myeloid leukemia (AML) is an aggressive hematological malignancy, associated with unfavorable patient outcome, primarily due to disease relapse. Mesenchymal stem cells (MSCs) residing in the bone marrow (BM) niche are the source of mesenchyma-derived subpopulations, includi...

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Detalhes bibliográficos

Principais autores:	Rawan Sabbah, Sahar Saadi, Tal Shahar-Gabay, Shiran Gerassy, Shlomit Yehudai-Resheff, Tsila Zuckerman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-10-01
coleção:	Cell Communication and Signaling
Assuntos:	Mesenchymal stem cells Bone marrow niche Acute myeloid leukemia Adipocytes Osteocytes
Acesso em linha:	https://doi.org/10.1186/s12964-023-01231-z
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