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Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulators down regulate this exaggerated proinflammatory r...

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Principais autores: Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2020-03-01
coleção:eLife
Assuntos:
ivacaftor
lumacaftor
tezacaftor
cystic fibrosis
inflammation
nlrp3 inflammasome
Acesso em linha:https://elifesciences.org/articles/54556
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