Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells

Summary: The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways. Through a genome-wide siRNA screen combined with RNA sequencing analysis, we identified hexokinase and downstream O-GlcNAcylation as cell...

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Bibliografische Detailangaben

Hauptverfasser:	Eiichi Hashimoto, Shota Okuno, Shoshiro Hirayama, Yoshiyuki Arata, Tsuyoshi Goto, Hidetaka Kosako, Jun Hamazaki, Shigeo Murata
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-07-01
Schriftenreihe:	iScience
Schlagworte:	Biological Sciences Cell Biology Functional Aspects of Cell Biology Cancer
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004220304867
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