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Small colony variants and cefiderocol resistance in clinical Escherichia coli: an in vitro mechanistic study

BackgroundThe emergence of cefiderocol resistance in Escherichia coli poses a threat to this last line antibiotic against carbapenem-resistant infections. This study aimed to induce and characterize the mechanisms of cefiderocol resistance in vitro.MethodsCefiderocol resistance was induced in four c...

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Principais autores: Muhammad Ali Syed, Danni Pu, Rongrong Song, Jiankang Zhao, Bin Cao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Microbiology
Assuntos:
antibiotic resistance
cefiderocol
Escherichia coli
small colony variants
whole genome sequencing
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmicb.2026.1761368/full
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