PKMζ-PKCι/λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

PKMζ is a persistently active atypical PKC (aPKC) isoform thought to maintain late-phase long-term potentiation (late-LTP) and long-term memory. PKMζ-knockout mice, however, still exhibit hippocampal LTP and spatial memory while lacking neocortical LTP, questioning whether this kinase is fundamental...

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Hlavní autoři:	Panayiotis Tsokas, Changchi Hsieh, Alejandro Grau-Perales, Andrew Tcherepanov, Leo Kwok, Laura Rodriguez-Valencia, David A Cano, Kim Allen, Hannah J Smith, Sabina Kubayeva, Benson J Wei, Samuel Sabzanov, Rafael Flores-Obando, Sourav Ghosh, Peter John Bergold, Jerry Rudy, James Cottrell, André Fenton, Todd Charlton Sacktor
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2026-07-01
Edice:	eLife
Témata:	PKMζ PKMzeta PKM-zeta PKCι/λ PKCι PKCiota
On-line přístup:	https://elifesciences.org/articles/110499
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