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Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1

Abstract Herpesviruses are known to acquire several genes from their hosts during evolution. We found that a significant proportion of virus homologues encoded by HSV-1, HSV-2, EBV and KSHV and their human counterparts contain G-quadruplex motifs in their promoters. We sought to understand the role...

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Autors principals: Shivani Kumar, Chitteti Ramamurthy, Divya Choudhary, Aashika Sekar, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-03-01
Col·lecció:Scientific Reports
Accés en línia:https://doi.org/10.1038/s41598-022-08161-9
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