Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts

Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e.g., endothelial cells, fibroblasts, and immune cells). Adipose tissue also represents a crucial...

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Principais autores:	Elena Andreucci, Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Alessio Biagioni, Eloisa Romano, Lido Calorini, Mirko Manetti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-03-01
Colecção:	Cells
Assuntos:	adipocytes adipose-derived stem cells cell differentiation extracellular acidosis lactate myofibroblasts
Acesso em linha:	https://www.mdpi.com/2073-4409/12/6/939
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