Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance
Abstract Missense mutations that inactivate p53 are common in cancer. LiFraumeni syndrome, which is linked to early-onset cancer, is caused by germline mutations in TP53. Full-penetrant, inactive variants have garnered great attention, whereas low-penetrant variants are less well understood despite...
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| Principais autores: | , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Portfolio
2026-04-01
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| סדרה: | npj Genomic Medicine |
| גישה מקוונת: | https://doi.org/10.1038/s41525-026-00568-x |
| תגים: |
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