Semisynthetic Amides of Amphotericin B and Nystatin A₁: A Comparative Study of In Vitro Activity/Toxicity Ratio in Relation to Selectivity to Ergosterol Membranes

Polyene antifungal amphotericin B (AmB) has been used for over 60 years, and remains a valuable clinical treatment for systemic mycoses, due to its broad antifungal activity and low rate of emerging resistance. There is no consensus on how exactly it kills fungal cells but it is certain that AmB and...

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Detalhes bibliográficos

Principais autores:	Anna Tevyashova, Svetlana Efimova, Alexander Alexandrov, Olga Omelchuk, Eslam Ghazy, Elena Bychkova, Georgy Zatonsky, Natalia Grammatikova, Lyubov Dezhenkova, Svetlana Solovieva, Olga Ostroumova, Andrey Shchekotikhin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-01-01
coleção:	Antibiotics
Assuntos:	polyene antibiotics amphotericin b nystatin semisynthetic derivatives amidation water-soluble
Acesso em linha:	https://www.mdpi.com/2079-6382/12/1/151
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