Prognostic significance of PNH clones in aplastic anemia treated with immunosuppression or allogeneic HSCT: a 20-year single-center experience

Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) clones are detected in up to 60% of patients with aplastic anemia (AA); however, their prognostic impact remains incompletely defined, particularly in the context of frontline immunosuppressive therapy (IST) or allogeneic hematopoietic st...

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Autori principali:	Alfadil Haroon, Hazzaa Alzahrani, Mostafa F. Mohammed Saleh, Ali Aalahmari, Shaykhah Alotaibi, Tusneem Elhassan, Feras Alfraih, Fahad Alsharif, Syed O. Ahmed, Fahad Almohareb, Riad El Fakih, Mahmoud Aljurf
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2026-04-01
Serie:	Blood Research
Soggetti:	Aplastic anemia PNH clone Immunosuppressive therapy Allogeneic stem cell transplantation Prognosis GVHD
Accesso online:	https://doi.org/10.1007/s44313-026-00136-3
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