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Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling

BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES The aim of this work was to perform m...

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Kaydedildi:
Asıl Yazarlar: Ana Carolina Rennó Sodero, Bárbara Abrahim-Vieira, Pedro Henrique Monteiro Torres, Pedro Geraldo Pascutti, Célia RS Garcia, Vitor Francisco Ferreira, David Rodrigues da Rocha, Sabrina Baptista Ferreira, Floriano Paes Silva Jr
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Fundação Oswaldo Cruz (FIOCRUZ)
Seri Bilgileri:Memorias do Instituto Oswaldo Cruz
Konular:
atovaquone
Plasmodium falciparum
molecular docking
surflex-dock
AutoDock4.2
Online Erişim:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000400299&lng=en&tlng=en
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